Full Service High Pressure Freezing and Freeze Substitution Specimen Preparation projects taken on a case by case basis and as time allows within the lab.

 is designed to freeze non-cryoprotected samples up to 0.5mm in thickness without significant ice crystal damage. Samples can then be processed for TEM using the freeze substitution protocol. These two methods are the state-of-the-art for TEM specimen preparation.

Full Service HPF-FS Specimen Preparation

The Electron Microscope Laboratory (EML) is an imaging core and shared resource facility of the University of California at Berkeley.  Our mission is to provide high-quality electron microscopy services, education, and training for the UC Berkeley campus, other academic institutions, and private companies at-large.

The lab is equipped with high resolution transmission electron microscopes, scanning electron microscopes, high pressure freezer and full suite of ancillary sample preparation equipment to fit most EM-related needs. The equipment can provide nanometer scale analysis for biological, chemical and materials science.  

The EML offers multiple levels of service that correspond with the services and training each user desires:

All services are available to non-UC users.  

Please note, the EML now provides fee-for-service full service microscopy for campus and external users as our staff availability allows on an 

All external, non-UCB customers are required to comply with all UC visitor policies and lab rules.

UCB Electron Microscope Lab

NOTE: Access to UC Berkeley facilities and services requires university approval which takes as little as 24 hours. First time UC Berkeley users on Second Lab will be prompted to complete approval requirements during checkout. 

Full Service HPF-FS Specimen Preparation

Submission Guideline

Lab Information